Luke Lois graduated from Rochester Institute of Technology in 1984 with a BFA in Photography, when he opened Luke Lois Photography and worked with award-winning art directors such as Lou Dorfsman, Reba Sochis, Tony Palladino, and, of course, George Lois. His passion in photography was portraiture but the bulk of his work was advertising, creating images for clients such as USA Today, Time magazine, Tommy HIlfiger, ESPN, Balanciaga, Jiffy Lube, InterContinental Hotels, Hertz, working with advertising agencies such as Wells Rich Greene, Tarlow Advertising, and Lois/USA.

In 2000, he started Good Karma Creative. Teamed with his father George Lois, together they have been designing books ($ellebrity, Ali Rap, Iconic America, Creation of the Big Idea, The Esquire Covers @ MoMA, Damn Good Advice, and Lois Logos), while creating advertising campaigns for AmericanLife TV, Superfocus eyeglasses, OMGFast hi-speed internet, Travalo perfume atomizers, SOMA cellular communications app, as well as creating logos and branding products and companies.

Additionally, Luke is in the midst of producing a documentary film on his father George Lois, working with his son (also George Lois) and Alen Petkovic.